|Other Names||Transcription factor AP-1, Activator protein 1, AP1, Proto-oncogene c-Jun, V-jun avian sarcoma virus 17 oncogene homolog, p39, JUN|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).|
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This gene is the putative transforming gene of aviansarcoma virus 17. It encodes a protein which is highly similar tothe viral protein, and which interacts directly with specifictarget DNA sequences to regulate gene expression. This gene isintronless and is mapped to 1p32-p31, a chromosomal region involvedin both translocations and deletions in human malignancies.
Gonsalves, C., et al. J. Immunol. 185(10):6253-6264(2010)Bozec, A., et al. J. Cell Biol. 190(6):1093-1106(2010)Machida, K., et al. Hepatology 52(2):480-492(2010)Madi, A., et al. BMC Microbiol. 10, 215 (2010) :Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
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