|Other Names||DNA repair protein XRCC4, X-ray repair cross-complementing protein 4, XRCC4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.|
|Tissue Location||Widely expressed.|
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The protein encoded by this gene functions together withDNA ligase IV and the DNA-dependent protein kinase in the repair ofDNA double-strand break by non-homologous end joining and thecompletion of V(D)J recombination events. The non-homologousend-joining pathway is required both for normal development and forsuppression of tumors. This gene functionally complements XR-1Chinese hamster ovary cell mutant, which is impaired in DNAdouble-strand breaks produced by ionizing radiation and restrictionenzymes. Alternative transcription initiation and alternativesplicing generates several transcript variants. [provided byRefSeq].
Gomes, B.C., et al. Oncol. Rep. 24(4):1079-1085(2010)Liu, Y., et al. Carcinogenesis 31(10):1762-1769(2010)Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)Liu, N., et al. Wei Sheng Yan Jiu 39(4):407-411(2010)Bau, D.T., et al. Anticancer Res. 30(7):2727-2730(2010)
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