|Other Names||N-acetylneuraminate lyase, NALase, N-acetylneuraminate pyruvate-lyase, N-acetylneuraminic acid aldolase, Sialate lyase, Sialate-pyruvate lyase, Sialic acid aldolase, Sialic acid lyase, NPL, C1orf13|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N- glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (By similarity).|
|Tissue Location||Isoform 2 is expressed in placenta, liver, kidney, pancreas, spleen, thymus, ovary, small intestine and peripheral blood leukocyte.|
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Provided below are standard protocols that you may find useful for product applications.
N-acetylneuraminate pyruvate lyase (EC 18.104.22.168) controlsthe cellular concentration of sialic acid by catalyzing theconversion of sialic acid into acylmannosamines and pyruvate (Wu etal., 2005 [PubMed 16147865]).
Chu, H.Y., et al. J Mol Model 15(3):323-328(2009)Wu, M., et al. DNA Seq. 16(2):137-142(2005)Traving, C., et al. Eur. J. Biochem. 268(24):6473-6486(2001)Sood, R., et al. Genomics 73(2):211-222(2001)
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