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NPL Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9BXD5
Clone Names 110712013
Additional Information
Gene ID 80896
Other Names N-acetylneuraminate lyase, NALase, N-acetylneuraminate pyruvate-lyase, N-acetylneuraminic acid aldolase, Sialate lyase, Sialate-pyruvate lyase, Sialic acid aldolase, Sialic acid lyase, NPL, C1orf13
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NPL (HGNC:16781)
Synonyms C1orf13
Function Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate (PubMed:33895133). It prevents sialic acids from being recycled and returning to the cell surface (PubMed:33895133). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (PubMed:22692205, PubMed:33895133). Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (Probable).
Cellular Location Cytoplasm.
Tissue Location Isoform 2 is expressed in placenta, liver, kidney, pancreas, spleen, thymus, ovary, small intestine and peripheral blood leukocyte.
Research Areas
Citations (0)
citation

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Background

N-acetylneuraminate pyruvate lyase (EC 4.1.3.3) controlsthe cellular concentration of sialic acid by catalyzing theconversion of sialic acid into acylmannosamines and pyruvate (Wu etal., 2005 [PubMed 16147865]).

References

Chu, H.Y., et al. J Mol Model 15(3):323-328(2009)Wu, M., et al. DNA Seq. 16(2):137-142(2005)Traving, C., et al. Eur. J. Biochem. 268(24):6473-6486(2001)Sood, R., et al. Genomics 73(2):211-222(2001)

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$ 277.78
Cat# BP18910a
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