|Other Names||Sphingosine 1-phosphate receptor 2, S1P receptor 2, S1P2, Endothelial differentiation G-protein coupled receptor 5, Sphingosine 1-phosphate receptor Edg-5, S1P receptor Edg-5, S1PR2, EDG5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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This gene encodes a member of the G protein-coupledreceptors, as well as the EDG family of proteins. This proteinparticipates in sphingosine 1-phosphate-induced cell proliferation,survival, and transcriptional activation
Oskeritzian, C.A., et al. J. Exp. Med. 207(3):465-474(2010)McGeachie, M., et al. Circulation 120(24):2448-2454(2009)Cattoretti, G., et al. Cancer Res. 69(22):8686-8692(2009)Randriamboavonjy, V., et al. Basic Res. Cardiol. 104(3):333-340(2009)Li, M.H., et al. Mol. Cancer Res. 6(10):1649-1656(2008)
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