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FAF2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96CS3 |
|---|---|
| Clone Names | 110726055 |
| Gene ID | 23197 |
|---|---|
| Other Names | FAS-associated factor 2, Protein ETEA, UBX domain-containing protein 3B, UBX domain-containing protein 8, FAF2, ETEA, KIAA0887, UBXD8, UBXN3B |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | FAF2 {ECO:0000303|PubMed:34739333, ECO:0000312|HGNC:HGNC:24666} |
|---|---|
| Function | Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:18711132, PubMed:24215460). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis (PubMed:23297223). Involved in stress granule disassembly: associates with ubiquitinated G3BP1 in response to heat shock, thereby promoting interaction between ubiquitinated G3BP1 and VCP, followed by G3BP1 extraction from stress granules and stress granule disassembly (PubMed:34739333). |
| Cellular Location | Cytoplasm. Lipid droplet Endoplasmic reticulum |
| Tissue Location | Broadly expressed, with highest levels in brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is highly expressed inperipheral blood of patients with atopic dermatitis (AD), comparedto normal individuals. It may play a role in regulating theresistance to apoptosis that is observed in T cells and eosinophilsof AD patients.
References
Phan, V.T., et al. Mol. Cell. Biol. 30(9):2264-2279(2010)Ernst, R., et al. Mol. Cell 36(1):28-38(2009)Alexandru, G., et al. Cell 134(5):804-816(2008)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Imai, Y., et al. Biochem. Biophys. Res. Commun. 297(5):1282-1290(2002)
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