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FAF2 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q96CS3
Clone Names 110726055
Peptide ID 110726055
Additional Information
Gene ID 23197
Other Names FAS-associated factor 2, Protein ETEA, UBX domain-containing protein 3B, UBX domain-containing protein 8, FAF2, ETEA, KIAA0887, UBXD8, UBXN3B
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FAF2
Synonyms ETEA, KIAA0887, UBXD8, UBXN3B
Function Plays an important role in endoplasmic reticulum- associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:18711132, PubMed:24215460). Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis (PubMed:23297223).
Cellular Location Cytoplasm. Lipid droplet. Endoplasmic reticulum
Tissue Location Broadly expressed, with highest levels in brain.
Research Areas
Citations (0)

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Background

The protein encoded by this gene is highly expressed inperipheral blood of patients with atopic dermatitis (AD), comparedto normal individuals. It may play a role in regulating theresistance to apoptosis that is observed in T cells and eosinophilsof AD patients.

References

Phan, V.T., et al. Mol. Cell. Biol. 30(9):2264-2279(2010)Ernst, R., et al. Mol. Cell 36(1):28-38(2009)Alexandru, G., et al. Cell 134(5):804-816(2008)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Imai, Y., et al. Biochem. Biophys. Res. Commun. 297(5):1282-1290(2002)

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$ 80.00
Cat# BP18912b
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