|Other Names||Inward rectifier potassium channel 18, Inward rectifier K(+) channel Kir26, Potassium channel, inwardly rectifying subfamily J member 18, KCNJ18|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Specifically expressed in skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
Inwardly rectifying potassium channels, such as KCNJ18,maintain resting membrane potential in excitable cells and aid inrepolarization of cells following depolarization. KCNJ18 isprimarily expressed in skeletal muscle and is transcriptionallyregulated by thyroid hormone (Ryan et al., 2010 [PubMed20074522]).
Ryan, D.P., et al. Cell 140(1):88-98(2010)
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