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NUBP1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P53384 |
|---|---|
| Clone Names | 110717133 |
| Gene ID | 4682 |
|---|---|
| Other Names | Cytosolic Fe-S cluster assembly factor NUBP1 {ECO:0000255|HAMAP-Rule:MF_03038}, Nucleotide-binding protein 1 {ECO:0000255|HAMAP-Rule:MF_03038}, NBP 1 {ECO:0000255|HAMAP-Rule:MF_03038}, NUBP1 {ECO:0000255|HAMAP-Rule:MF_03038}, NBP, NBP1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NUBP1 {ECO:0000255|HAMAP-Rule:MF_03038} |
|---|---|
| Synonyms | NBP, NBP1 |
| Function | Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery (PubMed:18573874). Required for maturation of extramitochondrial Fe-S proteins (PubMed:18573874). The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (PubMed:18573874). Implicated in the regulation of centrosome duplication (By similarity). Negatively regulates cilium formation and structure (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03038, ECO:0000269|PubMed:18573874, ECO:0000269|PubMed:29848660}. Nucleus {ECO:0000250|UniProtKB:Q9R060}. Cell projection {ECO:0000250|UniProtKB:Q9R060}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q9R060}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9R060}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:Q9R060} Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q9R060}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Enriched in centrioles of microtubule asters during prophase, prometaphase and telophase stages of mitosis. Localized at centrioles and in the nucleus at interphase. Colocalizes with nubp-2 at prometaphase. Specifically localizes to the axenome of motile cilia as opposed to primary non- motile cilia. Localization is independent of NUBP2 and KIFC1 {ECO:0000250|UniProtKB:Q9R060} |
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Provided below are standard protocols that you may find useful for product applications.
Background
NUBP1 is a member of the NUBP/MRP subfamily of ATP-bindingproteins (Nakashima et al., 1999 [PubMed 10486206]).[supplied byOMIM].
References
Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)Shen, M., et al. Environ. Mol. Mutagen. 50(4):285-290(2009)Hosgood, H.D. III, et al. Carcinogenesis 29(10):1938-1943(2008)Stehling, O., et al. Mol. Cell. Biol. 28(17):5517-5528(2008)Taniguchi, N., et al. J. Biol. Chem. 275(41):31674-31681(2000)
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