|Other Names||Ras-related GTP-binding protein B, Rag B, RagB, RRAGB (HGNC:19901)|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway.|
|Cellular Location||Cytoplasm. Lysosome|
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Provided below are standard protocols that you may find useful for product applications.
Ras-homologous GTPases constitute a large family of signaltransducers that alternate between an activated, GTP-binding stateand an inactivated, GDP-binding state. These proteins representcellular switches that are operated by GTP-exchange factors andfactors that stimulate their intrinsic GTPase activity. All GTPasesof the Ras superfamily have in common the presence of six conservedmotifs involved in GTP/GDP binding, three of which arephosphate-/magnesium-binding sites (PM1-PM3) and three of which areguanine nucleotide-binding sites (G1-G3). Transcript variantsencoding distinct isoforms have been identified. [provided byRefSeq].
Ross, M.T., et al. Nature 434(7031):325-337(2005)Tomarev, S.I., et al. Invest. Ophthalmol. Vis. Sci. 44(6):2588-2596(2003)Sekiguchi, T., et al. J. Biol. Chem. 276(10):7246-7257(2001)Hirose, E., et al. J. Cell. Sci. 111 (PT 1), 11-21 (1998) :Schurmann, A., et al. J. Biol. Chem. 270(48):28982-28988(1995)
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