|Other Names||Sodium channel protein type 5 subunit alpha, HH1, Sodium channel protein cardiac muscle subunit alpha, Sodium channel protein type V subunit alpha, Voltage-gated sodium channel subunit alpha Nav15, SCN5A|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Found in jejunal circular smooth muscle cells (at protein level). Expressed in human atrial and ventricular cardiac muscle but not in adult skeletal muscle, brain, myometrium, liver, or spleen. Isoform 4 is expressed in brain|
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The protein encoded by this gene is an integral membraneprotein and tetrodotoxin-resistant voltage-gated sodium channelsubunit. This protein is found primarily in cardiac muscle and isresponsible for the initial upstroke of the action potential in anelectrocardiogram. Defects in this gene are a cause of long QTsyndrome type 3 (LQT3), an autosomal dominant cardiac disease.Alternative splicing results in several transcript variantsencoding different isoforms.
Liu, M., et al. Circ. Res. 107(8):967-974(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)van Stuijvenberg, L., et al. DNA Cell Biol. 29(10):577-587(2010)House, C.D., et al. Cancer Res. 70(17):6957-6967(2010)Garcia-Castro, M., et al. Rev Esp Cardiol 63(7):856-859(2010)
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