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SCN5A Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q14524
Clone Names 110729016
Peptide ID 110729016
Additional Information
Gene ID 6331
Other Names Sodium channel protein type 5 subunit alpha, HH1, Sodium channel protein cardiac muscle subunit alpha, Sodium channel protein type V subunit alpha, Voltage-gated sodium channel subunit alpha Nav15, SCN5A
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SCN5A
Function This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels.
Cellular Location Membrane; Multi-pass membrane protein
Tissue Location Found in jejunal circular smooth muscle cells (at protein level). Expressed in human atrial and ventricular cardiac muscle but not in adult skeletal muscle, brain, myometrium, liver, or spleen. Isoform 4 is expressed in brain
Research Areas
Citations (0)

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The protein encoded by this gene is an integral membraneprotein and tetrodotoxin-resistant voltage-gated sodium channelsubunit. This protein is found primarily in cardiac muscle and isresponsible for the initial upstroke of the action potential in anelectrocardiogram. Defects in this gene are a cause of long QTsyndrome type 3 (LQT3), an autosomal dominant cardiac disease.Alternative splicing results in several transcript variantsencoding different isoforms.


Liu, M., et al. Circ. Res. 107(8):967-974(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)van Stuijvenberg, L., et al. DNA Cell Biol. 29(10):577-587(2010)House, C.D., et al. Cancer Res. 70(17):6957-6967(2010)Garcia-Castro, M., et al. Rev Esp Cardiol 63(7):856-859(2010)

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$ 80.00
Cat# BP18938a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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