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ATPIF1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UII2 |
|---|---|
| Clone Names | 110826037 |
| Gene ID | 93974 |
|---|---|
| Other Names | ATPase inhibitor, mitochondrial, Inhibitor of F(1)F(o)-ATPase, IF(1), IF1, ATPIF1, ATPI |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ATP5IF1 (HGNC:871) |
|---|---|
| Synonyms | ATPI, ATPIF1 |
| Function | Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme. |
| Cellular Location | Mitochondrion. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a mitochondrial ATPase inhibitor.Alternative splicing occurs at this locus and three transcriptvariants encoding distinct isoforms have been identified. [providedby RefSeq].
References
Sanchez-Cenizo, L., et al. J. Biol. Chem. 285(33):25308-25313(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Li, N., et al. Int. J. Neurosci. 120(3):217-221(2010)Contessi, S., et al. J. Bioenerg. Biomembr. 39(4):291-300(2007)Ma, J., et al. Atherosclerosis 191(1):63-72(2007)
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