|Other Names||Testis-specific chromodomain protein Y 1, CDY1, CDY1A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has histone acetyltransferase activity, with a preference for histone H4.|
|Tissue Location||Testis-specific. Detected in spermatids (at protein level).|
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This gene encodes a protein containing a chromodomain anda histone acetyltransferase catalytic domain. Chromodomain proteinsare components of heterochromatin-like complexes and can act asgene repressors. This protein is localized to the nucleus of latespermatids where histone hyperacetylation takes place. Histonehyperacetylation is thought to facilitate the transition in whichprotamines replace histones as the major DNA-packaging protein. Thehuman chromosome Y has two identical copies of this gene within apalindromic region; this record represents the more centromericcopy. Chromosome Y also contains a pair of closely related genes inanother more telomeric palindrome as well as several relatedpseudogenes. Two protein isoforms are encoded by transcriptvariants of this gene. Additional transcript variants have beendescribed, but their full-length nature has not been determined.
Kleiman, S.E., et al. Hum. Genet. 113(6):486-492(2003)Dorus, S., et al. Hum. Mol. Genet. 12(14):1643-1650(2003)Skaletsky, H., et al. Nature 423(6942):825-837(2003)Lahn, B.T., et al. Proc. Natl. Acad. Sci. U.S.A. 99(13):8707-8712(2002)Ferlin, A., et al. J. Endocrinol. Invest. 24 (2), RC4-RC6 (2001) :
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