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CLEC2D Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UHP7 |
|---|---|
| Clone Names | 110826084 |
| Gene ID | 29121 |
|---|---|
| Other Names | C-type lectin domain family 2 member D, Lectin-like NK cell receptor, Lectin-like transcript 1, LLT-1, Osteoclast inhibitory lectin, CLEC2D, CLAX, LLT1, OCIL |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CLEC2D |
|---|---|
| Synonyms | CLAX, LLT1, OCIL |
| Function | Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis (PubMed:20843815, PubMed:16339513). Inhibits osteoclast formation (PubMed:14753741, PubMed:15123656). Inhibits bone resorption (PubMed:14753741). Modulates the release of interferon-gamma (PubMed:15104121). Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656). |
| Cellular Location | Cell membrane; Single-pass type II membrane protein [Isoform 4]: Endoplasmic reticulum |
| Tissue Location | Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform 1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also expressed in B-cell lines and LPS-matured monocyte-derived dendritic cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the natural killer cellreceptor C-type lectin family. The encoded protein inhibitsosteoclast formation and contains a transmembrane domain near theN-terminus as well as the C-type lectin-like extracellular domain.Several alternatively spliced transcript variants have beenidentified for this gene.
References
Germain, C., et al. J. Biol. Chem. (2010) In press :Bambard, N.D., et al. Scand. J. Immunol. 71(3):210-219(2010)Skinningsrud, B., et al. J. Clin. Endocrinol. Metab. 93(9):3310-3317(2008)Rosen, D.B., et al. J. Immunol. 180(10):6508-6517(2008)Pineda, B., et al. Calcif. Tissue Int. 82(5):348-353(2008)
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