|Other Names||C-type lectin domain family 2 member D, Lectin-like NK cell receptor, Lectin-like transcript 1, LLT-1, Osteoclast inhibitory lectin, CLEC2D, CLAX, LLT1, OCIL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CLAX, LLT1, OCIL|
|Function||Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon- gamma. Binds high molecular weight sulfated glycosaminoglycans.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein. Cell surface Isoform 4: Endoplasmic reticulum.|
|Tissue Location||Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform 1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also expressed in B-cell lines and LPS-matured monocyte-derived dendritic cells|
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This gene encodes a member of the natural killer cellreceptor C-type lectin family. The encoded protein inhibitsosteoclast formation and contains a transmembrane domain near theN-terminus as well as the C-type lectin-like extracellular domain.Several alternatively spliced transcript variants have beenidentified for this gene.
Germain, C., et al. J. Biol. Chem. (2010) In press :Bambard, N.D., et al. Scand. J. Immunol. 71(3):210-219(2010)Skinningsrud, B., et al. J. Clin. Endocrinol. Metab. 93(9):3310-3317(2008)Rosen, D.B., et al. J. Immunol. 180(10):6508-6517(2008)Pineda, B., et al. Calcif. Tissue Int. 82(5):348-353(2008)
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