|Other Names||Solute carrier organic anion transporter family member 1B3, Liver-specific organic anion transporter 2, LST-2, Organic anion transporter 8, Organic anion-transporting polypeptide 8, OATP-8, Solute carrier family 21 member 8, SLCO1B3, LST2, OATP1B3, OATP8, SLC21A8|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||LST2, OATP1B3, OATP8, SLC21A8|
|Function||Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.|
|Cellular Location||Basolateral cell membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the central vein. Not detected in other tissues. Highly expressed in some cancer cell lines derived from colon, pancreas, liver and gall bladder|
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Provided below are standard protocols that you may find useful for product applications.
SLCO1B3 belongs to the organic anion transporter (OATP)family. OATPs are involved in the membrane transport of bile acids,conjugated steroids, thyroid hormone, eicosanoids, peptides, andnumerous drugs in many tissues (Mikkaichi et al., 2004 [PubMed14993604]).
Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)Weiner, M., et al. Antimicrob. Agents Chemother. 54(10):4192-4200(2010)Kang, T.W., et al. Hum. Mol. Genet. 19(18):3672-3678(2010)Takahashi, N., et al. J. Hum. Genet. (2010) In press :Justenhoven, C., et al. Breast Cancer Res. Treat. (2010) In press :
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