|Other Names||Membrane protein MLC1, MLC1, KIAA0027, WKL1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx.|
|Cellular Location||Membrane; Multi-pass membrane protein. Cell membrane. Cytoplasm, perinuclear region. Endoplasmic reticulum|
|Tissue Location||Expressed in the brain, with highest levels found in the amygdala, nucleus caudatus, thalamus and hippocampus|
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Provided below are standard protocols that you may find useful for product applications.
The function of this gene product is unknown; however,homology to other proteins suggests that it may be an integralmembrane transporter. Mutations in this gene have been associatedwith megalencephalic leukoencephalopathy with subcortical cysts, anautosomal recessive neurological disorder. Alternatively splicedtranscript variants encoding different isoforms have beenidentified.
Yis, U., et al. Turk. J. Pediatr. 52(2):179-183(2010)Lanciotti, A., et al. Neurobiol. Dis. 37(3):581-595(2010)Shukla, P., et al. Prenat. Diagn. 28(4):357-359(2008)Ambrosini, E., et al. Mol. Cell. Neurosci. 37(3):480-493(2008)Selch, S., et al. Biol. Psychiatry 61(10):1211-1214(2007)
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