|Other Names||Synaptotagmin-like protein 4, Exophilin-2, Granuphilin, SYTL4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity).|
|Cellular Location||Membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Note=Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles (By similarity).|
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This gene encodes a member of the synaptotagmin likeprotein family. Members of this family are characterized by anN-terminal Rab27 binding domain and C-terminal tandem C2 domains.The encoded protein binds specific small Rab GTPases and isinvolved in intracellular membrane trafficking. This protein bindsRab27 and may be involved in inhibiting dense core vesicleexocytosis. Alternate splicing results in multiple transcriptvariants that encode the same protein.
Plaisance, V., et al. J. Biol. Chem. 281(37):26932-26942(2006)Ciufo, L.F., et al. Mol. Biol. Cell 16(2):470-482(2005)Fukuda, M. J. Biol. Chem. 278(17):15390-15396(2003)Fukuda, M., et al. J. Biol. Chem. 277(42):39673-39678(2002)Torii, S., et al. Mol. Cell. Biol. 22(15):5518-5526(2002)
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