|Other Names||Melanocortin receptor 5, MC5-R, MC-2, MC5R|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in the brain but not in the melanoma cells|
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This gene encodes a member of the seven-pass transmembraneG protein-coupled melanocortin receptor protein family thatstimulate cAMP signal transduction. The encoded protein is areceptor for melanocyte-stimulating hormone and adrenocorticotropichormone and is suggested to play a role in sebum generation.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Miller, C.L., et al. Schizophr. Res. 113 (2-3), 259-267 (2009) :Frandberg, P.A., et al. Biochem. Biophys. Res. Commun. 236(2):489-492(1997)
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