|Other Names||GTP cyclohydrolase 1 feedback regulatory protein, GFRP, GTP cyclohydrolase I feedback regulatory protein, p35, GCHFR, GFRP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.|
|Cellular Location||Nucleus. Nucleus membrane. Cytoplasm, cytosol|
|Tissue Location||In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
GTP cyclohydrolase I feedback regulatory protein binds toand mediates tetrahydrobiopterin inhibition of GTP cyclohydrolaseI. The regulatory protein, GCHFR, consists of a homodimer. It ispostulated that GCHFR may play a role in regulating phenylalaninemetabolism in the liver and in the production of biogenic amineneurotransmitters and nitric oxide.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)McHugh, P.C., et al. Pharmacogenomics J. (2010) In press :Li, L., et al. Circ. Res. 106(2):328-336(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Schnetz-Boutaud, N.C., et al. Genes Brain Behav. 8(8):753-757(2009)
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