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GCHFR Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P30047 |
|---|---|
| Clone Names | 100324032 |
| Gene ID | 2644 |
|---|---|
| Other Names | GTP cyclohydrolase 1 feedback regulatory protein, GFRP, GTP cyclohydrolase I feedback regulatory protein, p35, GCHFR, GFRP |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GCHFR |
|---|---|
| Synonyms | GFRP |
| Function | Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. |
| Cellular Location | Nucleus. Nucleus membrane. Cytoplasm, cytosol |
| Tissue Location | In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
GTP cyclohydrolase I feedback regulatory protein binds toand mediates tetrahydrobiopterin inhibition of GTP cyclohydrolaseI. The regulatory protein, GCHFR, consists of a homodimer. It ispostulated that GCHFR may play a role in regulating phenylalaninemetabolism in the liver and in the production of biogenic amineneurotransmitters and nitric oxide.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)McHugh, P.C., et al. Pharmacogenomics J. (2010) In press :Li, L., et al. Circ. Res. 106(2):328-336(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Schnetz-Boutaud, N.C., et al. Genes Brain Behav. 8(8):753-757(2009)
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