|Other Names||Solute carrier organic anion transporter family member 1C1, Organic anion transporter F, OATP-F, Organic anion transporter polypeptide-related protein 5, OAT-RP-5, OATPRP5, Organic anion-transporting polypeptide 14, OATP-14, Solute carrier family 21 member 14, Thyroxine transporter, SLCO1C1, OATP14, OATP1C1, OATPF, SLC21A14|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||OATP14, OATP1C1, OATPF, SLC21A14|
|Function||Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role in regulating T4 flux into and out of the brain (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein Note=Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus (By similarity).|
|Tissue Location||Highly expressed in brain and in Leydig cells in testis. Detected in many brain regions with the exception of pons and cerebellum. Not strongly enriched in cerebral microvessels.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the organic aniontransporter family. The encoded protein is a transmembrane receptorthat mediates the sodium-independent uptake of thyroid hormones inbrain tissues. This protein has particularly high affinity for thethyroid hormones thyroxine, tri-iodothyronine and reversetri-iodothyronine. Polymorphisms in the gene encoding this proteinmay be associated with fatigue and depression in patients sufferingfrom hyperthyroidism. Alternative splicing results in multipletranscript variants.
Franke, R.M., et al. Pharmacogenomics 10(3):339-344(2009)Heuer, H., et al. Endocrinology 150(3):1078-1083(2009)Leuthold, S., et al. Am. J. Physiol., Cell Physiol. 296 (3), C570-C582 (2009) :Westholm, D.E., et al. Endocrinology 150(2):1025-1032(2009)Roberts, L.M., et al. Endocrinology 149(12):6251-6261(2008)
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