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SLCO1C1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NYB5 |
|---|---|
| Clone Names | 100324034 |
| Gene ID | 53919 |
|---|---|
| Other Names | Solute carrier organic anion transporter family member 1C1, Organic anion transporter F, OATP-F, Organic anion transporter polypeptide-related protein 5, OAT-RP-5, OATPRP5, Organic anion-transporting polypeptide 14, OATP-14, Solute carrier family 21 member 14, Thyroxine transporter, SLCO1C1, OATP14, OATP1C1, OATPF, SLC21A14 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLCO1C1 |
|---|---|
| Synonyms | OATP14, OATP1C1, OATPF, SLC21A14 |
| Function | Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones L-thyroxine (T4), L- thyroxine sulfate (T4S), and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) at the plasma membrane (PubMed:12351693, PubMed:18566113, PubMed:19129463). Regulates T4 levels in different brain regions by transporting T4, and also by serving as an export pump for T4S, which is a source of T4 after hydrolysis by local sulfatases (PubMed:18566113). Increases the access of these substrates to the intracellular sites where they are metabolized by the deiodinases (PubMed:18566113). Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D- glucuronate)), estrone-3-sulfate (E1S) and sulfobromophthalein (BSP) are transported with much lower efficiency (PubMed:12351693, PubMed:19129463). Transports T4 and E1S in a pH-insensitive manner (PubMed:19129463). Facilitates the transport of thyroid hormones across the blood-brain barrier and into glia and neuronal cells in the brain (PubMed:30296914). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Note=Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus |
| Tissue Location | Highly expressed in brain and in Leydig cells in testis (PubMed:12351693, PubMed:35307651). Localized in nests of Leydig cells (at protein level) (PubMed:12351693). Expressed in choroid plexus (at protein level) (PubMed:18687783). Not strongly enriched in cerebral microvessels (PubMed:18687783). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the organic aniontransporter family. The encoded protein is a transmembrane receptorthat mediates the sodium-independent uptake of thyroid hormones inbrain tissues. This protein has particularly high affinity for thethyroid hormones thyroxine, tri-iodothyronine and reversetri-iodothyronine. Polymorphisms in the gene encoding this proteinmay be associated with fatigue and depression in patients sufferingfrom hyperthyroidism. Alternative splicing results in multipletranscript variants.
References
Franke, R.M., et al. Pharmacogenomics 10(3):339-344(2009)Heuer, H., et al. Endocrinology 150(3):1078-1083(2009)Leuthold, S., et al. Am. J. Physiol., Cell Physiol. 296 (3), C570-C582 (2009) :Westholm, D.E., et al. Endocrinology 150(2):1025-1032(2009)Roberts, L.M., et al. Endocrinology 149(12):6251-6261(2008)
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