|Other Names||Amyloid beta A4 precursor protein-binding family A member 3, Adapter protein X11gamma, Neuron-specific X11L2 protein, Neuronal Munc18-1-interacting protein 3, Mint-3, APBA3, MINT3, X11L2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.|
|Cellular Location||Cytoplasm, perinuclear region|
|Tissue Location||Expressed in all tissues examined with lower levels in brain and testis|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the X11protein family. It is an adapter protein that interacts with theAlzheimer's disease amyloid precursor protein. This gene product isbelieved to be involved in signal transduction processes. This geneis a candidate gene for Alzheimer's disease.
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Swistowski, A., et al. J. Neurosci. 29(50):15703-15712(2009)Sakamoto, T., et al. J. Biol. Chem. 284(44):30350-30359(2009)Han, J., et al. J. Cell. Sci. 121 (PT 13), 2217-2223 (2008) :Shrivastava-Ranjan, P., et al. Mol. Biol. Cell 19(1):51-64(2008)
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