|Other Names||Tripartite motif-containing protein 35, Hemopoietic lineage switch protein 5, TRIM35, HLS5, KIAA1098|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (PubMed:25263439). Involved in the cell death mechanism (By similarity).|
|Cellular Location||Cytoplasm. Nucleus. Note=Found predominantly in cytoplasm with a granular distribution. Found in punctuate nuclear bodies (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of thetripartite motif (TRIM) family. The TRIM motif includes threezinc-binding domains, a RING, a B-box type 1 and a B-box type 2,and a coiled-coil region. The function of this protein has not beenidentified.
Lalonde, J.P., et al. J. Biol. Chem. 279(9):8181-8189(2004)Kimura, F., et al. J. Biol. Chem. 278(27):25046-25054(2003)Reymond, A., et al. EMBO J. 20(9):2140-2151(2001)
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