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TRIM35 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9UPQ4
Clone Names 100408321
Additional Information
Gene ID 23087
Other Names Tripartite motif-containing protein 35, Hemopoietic lineage switch protein 5, TRIM35, HLS5, KIAA1098
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM35
Synonyms HLS5, KIAA1098
Function E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response. Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via RIG-I signaling pathway (PubMed:32562145). Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2 (PubMed:32562145). Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling. Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway (PubMed:25907537). Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (PubMed:25263439).
Cellular Location Cytoplasm. Nucleus. Note=Found predominantly in cytoplasm with a granular distribution. Found in punctuate nuclear bodies (By similarity)
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene is a member of thetripartite motif (TRIM) family. The TRIM motif includes threezinc-binding domains, a RING, a B-box type 1 and a B-box type 2,and a coiled-coil region. The function of this protein has not beenidentified.

References

Lalonde, J.P., et al. J. Biol. Chem. 279(9):8181-8189(2004)Kimura, F., et al. J. Biol. Chem. 278(27):25046-25054(2003)Reymond, A., et al. EMBO J. 20(9):2140-2151(2001)

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$ 277.78
Cat# BP18985b
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