|Other Names||Transient receptor potential cation channel subfamily V member 4, TrpV4, Osm-9-like TRP channel 4, OTRPC4, Transient receptor potential protein 12, TRP12, Vanilloid receptor-like channel 2, Vanilloid receptor-like protein 2, VRL-2, Vanilloid receptor-related osmotically-activated channel, VR-OAC, TRPV4, VRL2, VROAC|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, adherens junction. Note=Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum Isoform 5: Cell membrane.|
|Tissue Location||Found in the synoviocytes from patients with (RA) and without (CTR) rheumatoid arthritis (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the OSM9-like transientreceptor potential channel (OTRPC) subfamily in the transientreceptor potential (TRP) superfamily of ion channels. The encodedprotein is a Ca2+-permeable, nonselective cation channel that isthought to be involved in the regulation of systemic osmoticpressure. Mutations in this gene are the cause ofspondylometaphyseal and metatropic dysplasia and hereditary motorand sensory neuropathy type IIC. Multiple transcript variantsencoding different isoforms have been found for this gene.
Shukla, A.K., et al. J. Biol. Chem. 285(39):30115-30125(2010)Cantero-Recasens, G., et al. J. Biol. Chem. 285(36):27532-27535(2010)Loukin, S., et al. J. Biol. Chem. 285(35):27176-27181(2010)Nishimura, G., et al. Am. J. Med. Genet. A 152A (6), 1443-1449 (2010) :Zimon, M., et al. Brain 133 (PT 6), 1798-1809 (2010) :
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