|Other Names||Relaxin receptor 2, G-protein coupled receptor 106, G-protein coupled receptor affecting testicular descent, Leucine-rich repeat-containing G-protein coupled receptor 8, Relaxin family peptide receptor 2, RXFP2, GPR106, GREAT, LGR8|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||GPR106, GREAT, LGR8|
|Function||Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells and bone marrow|
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This gene encodes a member of the GPCR (G protein-coupled,7-transmembrane receptor) family. Mutations in this gene areassociated with cryptorchidism. Alternatively spliced transcriptvariants encoding different isoforms have been found for this gene.
Ars, E., et al. Int. J. Androl. (2010) In press :Ferlin, A., et al. Ann. N. Y. Acad. Sci. 1160, 215-218 (2009) :Ferlin, A., et al. Ann. N. Y. Acad. Sci. 1160, 213-214 (2009) :Feng, S., et al. Ann. N. Y. Acad. Sci. 1160, 197-204 (2009) :Scott, D.J., et al. Ann. N. Y. Acad. Sci. 1160, 74-77 (2009) :
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