|Other Names||Actin-related protein 2/3 complex subunit 2, Arp2/3 complex 34 kDa subunit, p34-ARC, ARPC2, ARC34|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell projection. Cell junction, synapse, synaptosome|
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This gene encodes one of seven subunits of the humanArp2/3 protein complex. The Arp2/3 protein complex has beenimplicated in the control of actin polymerization in cells and hasbeen conserved through evolution. The exact role of the proteinencoded by this gene, the p34 subunit, has yet to be determined.Two alternatively spliced variants have been characterized to date.Additional alternatively spliced variants have been described buttheir full length nature has not been determined. [provided byRefSeq].
Monfregola, J., et al. J. Biol. Chem. 285(22):16951-16957(2010)Festen, E.A., et al. Am. J. Gastroenterol. 105(2):395-402(2010)Franke, A., et al. Nat. Genet. 40(11):1319-1323(2008)Xiao, F., et al. Brain Res. 1233, 168-175 (2008) :Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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