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RALA Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P11233
Clone Names 100525143
Peptide ID 100525143
Additional Information
Gene ID 5898
Other Names Ras-related protein Ral-A, RALA, RAL
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms RAL
Function Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin- dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.
Cellular Location Cell surface. Cell membrane; Lipid-anchor; Cytoplasmic side. Cleavage furrow. Midbody. Note=Prior to LPA treatment found predominantly at the cell surface and in the presence of LPA colocalizes with LPAR1 and LPAR2 in the endocytic vesicles. During early cytokinesis localizes at the cleavage furrow membrane. Colocalizes with EXOC2 at the early midbody ring and persists there till maturation of the midbody
Research Areas
Citations (0)

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The product of this gene belongs to the small GTPasesuperfamily, Ras family of proteins. GTP-binding proteins mediatethe transmembrane signaling initiated by the occupancy of certaincell surface receptors. This gene encodes a low molecular massras-like GTP-binding protein that shares about 50% similarity withother ras proteins.


Nichols, C.D., et al. Curr. Biol. 20(14):1316-1320(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Godin, C.M., et al. Mol. Pharmacol. 77(3):388-395(2010)Lim, K.H., et al. Mol. Cell. Biol. 30(2):508-523(2010)Wang, K., et al. Int J Immunopathol Pharmacol 22(3):735-743(2009)

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$ 80.00
Cat# BP18995b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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