|Other Names||ATP-sensitive inward rectifier potassium channel 1, ATP-regulated potassium channel ROM-K, Inward rectifier K(+) channel Kir11, Potassium channel, inwardly rectifying subfamily J member 1, KCNJ1, ROMK1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.|
|Cellular Location||Cell membrane; Multi-pass membrane protein Note=Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane|
|Tissue Location||In the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver.|
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Potassium channels are present in most mammalian cells,where they participate in a wide range of physiologic responses.The protein encoded by this gene is an integral membrane proteinand inward-rectifier type potassium channel. It is activated byinternal ATP and probably plays an important role in potassiumhomeostasis. The encoded protein has a greater tendency to allowpotassium to flow into a cell rather than out of a cell. Mutationsin this gene have been associated with antenatal Bartter syndrome,which is characterized by salt wasting, hypokalemic alkalosis,hypercalciuria, and low blood pressure. Multiple transcriptvariants encoding different isoforms have been found for this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Lin, D.H., et al. J. Biol. Chem. 284(43):29614-29624(2009)
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