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SSTR5 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P35346
Clone Names 100617310
Additional Information
Gene ID 6755
Other Names Somatostatin receptor type 5, SS-5-R, SS5-R, SS5R, SSTR5
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SSTR5
Function Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Adult pituitary gland, heart, small intestine, adrenal gland, cerebellum and fetal hypothalamus. No expression in fetal or adult kidney, liver, pancreas, uterus, spleen, lung, thyroid or ovary.
Research Areas
Citations (0)
citation

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Background

Somatostatin and its related peptide cortistatin exertmultiple biological actions on normal and tumoral tissue targets byinteracting with somatostatin receptors (SSTRs). The proteinencoded by this gene is one of the SSTRs, which is a multi-passmembrane protein and belongs to the G-protein coupled receptor 1family. The activity of this receptor is mediated by G proteinswhich inhibit adenylyl cyclase, and different regions of thisreceptor molecule are required for the activation of differentsignaling pathways. A mutation in this gene results in somatostatinanalog resistance. Alternatively spliced transcript variants havebeen identified in this gene.

References

Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :Duran-Prado, M., et al. J. Clin. Endocrinol. Metab. 95(5):2497-2502(2010)Pisarek, H., et al. Folia Histochem. Cytobiol. 48(1):142-147(2010)

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$ 277.78
Cat# BP19004b
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