|Other Names||Somatostatin receptor type 5, SS-5-R, SS5-R, SS5R, SSTR5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Adult pituitary gland, heart, small intestine, adrenal gland, cerebellum and fetal hypothalamus. No expression in fetal or adult kidney, liver, pancreas, uterus, spleen, lung, thyroid or ovary.|
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Provided below are standard protocols that you may find useful for product applications.
Somatostatin and its related peptide cortistatin exertmultiple biological actions on normal and tumoral tissue targets byinteracting with somatostatin receptors (SSTRs). The proteinencoded by this gene is one of the SSTRs, which is a multi-passmembrane protein and belongs to the G-protein coupled receptor 1family. The activity of this receptor is mediated by G proteinswhich inhibit adenylyl cyclase, and different regions of thisreceptor molecule are required for the activation of differentsignaling pathways. A mutation in this gene results in somatostatinanalog resistance. Alternatively spliced transcript variants havebeen identified in this gene.
Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :Duran-Prado, M., et al. J. Clin. Endocrinol. Metab. 95(5):2497-2502(2010)Pisarek, H., et al. Folia Histochem. Cytobiol. 48(1):142-147(2010)
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