|Other Names||Sodium- and chloride-dependent GABA transporter 1, GAT-1, Solute carrier family 6 member 1, SLC6A1, GABATR, GABT1, GAT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||GABATR, GABT1, GAT1|
|Function||Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane and in a subset of intracellular vesicles Localized at the presynaptic terminals of interneurons (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA)transporter, which removes GABA from the synaptic cleft (Hirunsatitet al., 2009 [PubMed 19077666]).
Yao, M., et al. J. Neurosci. 30(11):4062-4071(2010)Gonzalez-Burgos, G. Adv. Pharmacol. 58, 175-204 (2010) :Matthews, E. Jr., et al. Neurochem. Int. 55(8):732-740(2009)Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :Ben-Yona, A., et al. J. Biol. Chem. 284(15):9727-9732(2009)
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