|Other Names||Melanotransferrin, Melanoma-associated antigen p97, CD228, MFI2, MAP97|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.|
|Cellular Location||Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor|
|Tissue Location||Found predominantly in human melanomas and in certain fetal tissues; also found in liver, epithelium, umbilical chord, placenta and sweat gland ducts|
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The protein encoded by this gene is a cell-surfaceglycoprotein found on melanoma cells. The protein shares sequencesimilarity and iron-binding properties with members of thetransferrin superfamily. The importance of the iron bindingfunction has not yet been identified. This gene resides in the sameregion of chromosome 3 as members of the transferrin superfamily.Alternative splicing results in two transcript variants. [providedby RefSeq].
Wang, M., et al. J. Biol. Chem. 284(48):33377-33383(2009)Farnaud, S., et al. Int. J. Biochem. Cell Biol. 40(12):2739-2745(2008)Suryo Rahmanto, Y., et al. Carcinogenesis 28(10):2172-2183(2007)Suryo Rahmanto, Y., et al. Oncogene 26(42):6113-6124(2007)Michaud-Levesque, J., et al. Biol. Chem. 388(7):747-754(2007)
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