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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   Mouse Wee1 Antibody (Center) Blocking Peptide   

Mouse Wee1 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P47810
Clone Names 110328155
Peptide ID 110328155
Additional Information
Gene ID 22390
Other Names Wee1-like protein kinase, Wee1A kinase, Wee1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Wee1
Function Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation (By similarity).
Cellular Location Nucleus.
Research Areas
Citations (0)

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Background

Wee1 may act as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur (By similarity).

References

Muller, M., et al. J. Cell. Sci. 123 (PT 2), 286-294 (2010) :Kim, M.J., et al. Oncol. Rep. 19(5):1323-1329(2008)Tanaka, Y., et al. Biochem. Biophys. Res. Commun. 352(1):21-28(2007)Tominaga, Y., et al. Int. J. Biol. Sci. 2(4):161-170(2006)Park, C.E., et al. Cells Tissues Organs (Print) 177(4):221-228(2004)

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$ 80.00
Cat# BP19012c
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