|Other Names||Tubby-related protein 3, Tubby-like protein 3, TULP3, TUBL3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein- coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis.|
|Cellular Location||Nucleus. Cell membrane. Cell projection, cilium. Cytoplasm. Secreted. Note=Does not have a cleavable signal peptide and is secreted by a non- conventional pathway (By similarity). Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide- binding protein G(q) subunit alpha.|
|Tissue Location||Expressed at high levels in testis, ovaries, thyroid, and spinal chord.|
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This gene encodes a member of the tubby gene family ofbipartite transcription factors. Members of this family have beenidentified in plants, vertebrates, and invertebrates, and theyshare a conserved N-terminal transcription activation region and aconserved C-terminal DNA and phosphatidylinositol-phosphate bindingregion. The encoded protein binds to phosphoinositides in theplasma membrane via its C-terminal region and probably functions asa membrane-bound transcription regulator that translocates to thenucleus in response to phosphoinositide hydrolysis, for instance,induced by G-protein-coupled-receptor signaling. It plays animportant role in neuronal development and function. Two transcriptvariants encoding distinct isoforms have been identified for thisgene.
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Ikeda, A., et al. J. Cell. Sci. 115 (PT 1), 9-14 (2002) :Santagata, S., et al. Science 292(5524):2041-2050(2001)Ikeda, S., et al. Invest. Ophthalmol. Vis. Sci. 40(11):2706-2712(1999)Nishina, P.M., et al. Genomics 54(2):215-220(1998)
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