PAIP1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9H074 |
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Clone Names | 110901024 |
Gene ID | 10605 |
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Other Names | Polyadenylate-binding protein-interacting protein 1, PABP-interacting protein 1, PAIP-1, Poly(A)-binding protein-interacting protein 1, PAIP1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PAIP1 (HGNC:16945) |
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Function | Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. |
Cellular Location | Cytoplasm. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene interacts withpoly(A)-binding protein and with the cap-binding complex eIF4A. Itis involved in translational initiation and protein biosynthesis.Overexpression of this gene in COS7 cells stimulates translation.Alternative splicing occurs at this locus and three transcriptvariants encoding three distinct isoforms have been identified.
References
Kanaan, A.S., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65 (PT 10), 1060-1064 (2009) :Martineau, Y., et al. Mol. Cell. Biol. 28(21):6658-6667(2008)Fortna, A., et al. PLoS Biol. 2 (7), E207 (2004) :Roy, G., et al. Mol. Cell. Biol. 22(11):3769-3782(2002)Deo, R.C., et al. Proc. Natl. Acad. Sci. U.S.A. 98(8):4414-4419(2001)
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