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PDF Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9HBH1
Clone Names 110901040
Peptide ID 110901040
Additional Information
Gene ID 64146
Other Names Peptide deformylase, mitochondrial, Polypeptide deformylase, PDF, PDF1A
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDF
Synonyms PDF1A
Function Removes the formyl group from the N-terminal Met of newly synthesized proteins.
Cellular Location Mitochondrion.
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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Protein synthesis proceeds after formylation of methionineby methionyl-tRNA formyl transferase (FMT) and transfer of thecharged initiator f-met tRNA to the ribosome. In eubacteria andeukaryotic organelles the product of this gene, peptide deformylase(PDF), removes the formyl group from the initiating methionine ofnascent peptides. In eubacteria, deformylation of nascent peptidesis required for subsequent cleavage of initiating methionines bymethionine aminopeptidase. The discovery that a natural inhibitorof PDF, actinonin, acts as an antimicrobial agent in some bacteriahas spurred intensive research into the design ofbacterial-specific PDF inhibitors. In human cells, onlymitochondrial proteins have N-formylation of initiatingmethionines. Protein inhibitors of PDF or siRNAs of PDF block thegrowth of cancer cell lines but have no effect on normal cellgrowth. In humans, PDF function may therefore be restricted torapidly growing cells.


Escobar-Alvarez, S., et al. J. Mol. Biol. 387(5):1211-1228(2009)Wang, L., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3558-3566(2008)Lee, M.D., et al. J. Clin. Invest. 114(8):1107-1116(2004)Serero, A., et al. J. Biol. Chem. 278(52):52953-52963(2003)Lee, M.D., et al. Biochem. Biophys. Res. Commun. 312(2):309-315(2003)

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$ 80.00
Cat# BP19023c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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