|Other Names||Ras GTPase-activating protein 3, GAP1(IP4BP), Ins P4-binding protein, RASA3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.|
|Cellular Location||Cell membrane.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is member of the GAP1family of GTPase-activating proteins. The gene product stimulatesthe GTPase activity of normal RAS p21 but not its oncogeniccounterpart. Acting as a suppressor of RAS function, the proteinenhances the weak intrinsic GTPase activity of RAS proteinsresulting in the inactive GDP-bound form of RAS, thereby allowingcontrol of cellular proliferation and differentiation. This familymember is an inositol 1,3,4,5-tetrakisphosphate-binding protein,like the closely related RAS p21 protein activator 2. The twofamily members have distinct pleckstrin-homology domains, with thisparticular member having a domain consistent with its localizationto the plasma membrane.
Kupzig, S., et al. Mol. Cell. Biol. 29(14):3929-3940(2009)Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)Walker, S.A., et al. J. Biol. Chem. 277(50):48779-48785(2002)Koehler, J.A., et al. Biochem. Biophys. Res. Commun. 283(4):888-895(2001)Cozier, G.E., et al. J. Biol. Chem. 275(36):28261-28268(2000)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.