|Other Names||Ras GTPase-activating protein 3, GAP1(IP4BP), Ins P4-binding protein, RASA3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.|
|Cellular Location||Cell membrane.|
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The protein encoded by this gene is member of the GAP1family of GTPase-activating proteins. The gene product stimulatesthe GTPase activity of normal RAS p21 but not its oncogeniccounterpart. Acting as a suppressor of RAS function, the proteinenhances the weak intrinsic GTPase activity of RAS proteinsresulting in the inactive GDP-bound form of RAS, thereby allowingcontrol of cellular proliferation and differentiation. This familymember is an inositol 1,3,4,5-tetrakisphosphate-binding protein,like the closely related RAS p21 protein activator 2. The twofamily members have distinct pleckstrin-homology domains, with thisparticular member having a domain consistent with its localizationto the plasma membrane.
Kupzig, S., et al. Mol. Cell. Biol. 29(14):3929-3940(2009)Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)Walker, S.A., et al. J. Biol. Chem. 277(50):48779-48785(2002)Koehler, J.A., et al. Biochem. Biophys. Res. Commun. 283(4):888-895(2001)Cozier, G.E., et al. J. Biol. Chem. 275(36):28261-28268(2000)
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