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RREB1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q92766 |
|---|---|
| Clone Names | 110901123 |
| Gene ID | 6239 |
|---|---|
| Other Names | Ras-responsive element-binding protein 1, RREB-1, Finger protein in nuclear bodies, Raf-responsive zinc finger protein LZ321, Zinc finger motif enhancer-binding protein 1, Zep-1, RREB1, FINB |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RREB1 |
|---|---|
| Synonyms | FINB |
| Function | Transcription factor that binds specifically to the RAS- responsive elements (RRE) of gene promoters (PubMed:9305772, PubMed:15067362, PubMed:8816445, PubMed:10390538, PubMed:17550981). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). |
| Cellular Location | Nucleus speckle |
| Tissue Location | Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not found in the brain |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a zinc fingertranscription factor that binds to RAS-responsive elements (RREs)of gene promoters. It has been shown that the calcitonin genepromoter contains an RRE and that the encoded protein binds thereand increases expression of calcitonin, which may be involved inRas/Raf-mediated cell differentiation. Multiple transcript variantsencoding several different isoforms have been found for this gene.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Neale, B.M., et al. Proc. Natl. Acad. Sci. U.S.A. 107(16):7395-7400(2010)Milon, B.C., et al. Prostate 70(3):288-296(2010)Flajollet, S., et al. J. Immunol. 183(11):6948-6959(2009)Liu, H., et al. Biochem. J. 422(3):543-551(2009)
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