WHSC1L1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9BZ95 |
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Clone Names | 5041105 |
Gene ID | 54904 |
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Other Names | Histone-lysine N-methyltransferase NSD3, Nuclear SET domain-containing protein 3, Protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1, WHSC1-like protein 1, WHSC1L1, NSD3 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP1904a was selected from the C-term region of human WHSC1L1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | NSD3 (HGNC:12767) |
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Synonyms | WHSC1L1 |
Function | Histone methyltransferase. Preferentially dimethylates 'Lys- 4' and 'Lys-27' of histone H3 forming H3K2me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. |
Cellular Location | Nucleus. Chromosome. |
Tissue Location | Highly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung |
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Provided below are standard protocols that you may find useful for product applications.
Background
The gene for WHSC1L1 is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined.
References
Angrand, P.O., et al., Genomics 74(1):79-88 (2001).Stec, I., et al., FEBS Lett. 473(1):1-5 (2000).Stec, I., et al., Genomics 76 (1-3), 5-8 (2001) (): ().
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