|Other Names||Histone-lysine N-methyltransferase NSD3, Nuclear SET domain-containing protein 3, Protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1, WHSC1-like protein 1, WHSC1L1, NSD3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1904a was selected from the C-term region of human WHSC1L1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.|
|Cellular Location||Nucleus. Chromosome|
|Tissue Location||Highly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung|
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Provided below are standard protocols that you may find useful for product applications.
The gene for WHSC1L1 is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined.
Angrand, P.O., et al., Genomics 74(1):79-88 (2001).Stec, I., et al., FEBS Lett. 473(1):1-5 (2000).Stec, I., et al., Genomics 76 (1-3), 5-8 (2001) (): ().
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