|Other Names||DBIRD complex subunit ZNF326, Zinc finger protein 326, Zinc finger protein interacting with mRNPs and DBC1, ZNF326, ZIRD|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro.|
|Cellular Location||Nucleus matrix.|
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Probable transcriptional activator which may play a role in neuronal differentiation. Able to bind DNA and activate expression in vitro (By similarity).
O'Donnell, C.J., et al. BMC Med. Genet. 8 SUPPL 1, S4 (2007) :Andersen, J.S., et al. Nature 433(7021):77-83(2005)
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