|Other Names||Sperm protein associated with the nucleus on the X chromosome E, Nuclear-associated protein SPAN-Xe, SPANX-E, SPANX family member E, SPANXE|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Cytoplasm. Nucleus. Note=Associated with nuclear craters|
|Tissue Location||Detected in testis, sperm and a melanoma cell line.|
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Temporally regulated transcription and translation ofseveral testis-specific genes is required to initiate the series ofmolecular and morphological changes in the male germ cell lineagenecessary for the formation of mature spermatozoa. This gene is amember of the SPANX family of cancer/testis-associated genes, whichare located in a cluster on chromosome X. The SPANX genes encodedifferentially expressed testis-specific proteins that localize tovarious subcellular compartments. This particular gene encodes asperm protein that contains a consensus nuclear localization signalbut, although a role in spermatogenesis is suggested, the specificfunction of this family member has not yet been determined.
Hansen, S., et al. Syst Biol Reprod Med 55, 18-26 (2010) :Kouprina, N., et al. Genome Res. 15(11):1477-1486(2005)Zendman, A.J., et al. Gene 309(2):125-133(2003)Westbrook, V.A., et al. Biol. Reprod. 64(1):345-358(2001)
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