|Other Names||Surfeit locus protein 6, SURF6, SURF-6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity).|
|Cellular Location||Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Granular component of the nucleolus|
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This gene is located in the surfeit gene cluster, a groupof very tightly linked genes that do not share sequence similarity.The gene demonstrates features of a housekeeping gene, beingubiquitously expressed, and the encoded protein has been localizedto the nucleolus. The protein includes motifs found in both themouse and fish orthologs, which suggests a putative function as anucleolar-matrix protein with nucleic acid-binding properties,based on characteristics determined in mouse.
Polzikov, M., et al. Biochem. Biophys. Res. Commun. 327(1):143-149(2005)Andersen, J.S., et al. Nature 433(7021):77-83(2005)Angiolillo, A., et al. Gene 284 (1-2), 169-178 (2002) :Andersen, J.S., et al. Curr. Biol. 12(1):1-11(2002)Magoulas, C., et al. Gene 243 (1-2), 115-123 (2000) :
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