|Other Names||Taste receptor type 2 member 3, T2R3, TAS2R3|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin- positive cells. Expressed in the antrum and fundus (part of the stomach), duodenum and in gastric endocrine cells|
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This gene encodes a member of a family of candidate tastereceptors that are members of the G protein-coupled receptorsuperfamily and that are specifically expressed by taste receptorcells of the tongue and palate epithelia. These apparentlyintronless taste receptor genes encode a 7-transmembrane receptorprotein, functioning as a bitter taste receptor. This gene isclustered with another 3 candidate taste receptor genes inchromosome 7 and is genetically linked to loci that influencebitter perception.
Calvo, S.E., et al. Proc. Natl. Acad. Sci. U.S.A. 106(18):7507-7512(2009)Go, Y., et al. Genetics 170(1):313-326(2005)Fischer, A., et al. Mol. Biol. Evol. 22(3):432-436(2005)Zhang, Y., et al. Cell 112(3):293-301(2003)Montmayeur, J.P., et al. Curr. Opin. Neurobiol. 12(4):366-371(2002)
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