|Other Names||Lamina-associated polypeptide 2, isoforms beta/gamma, Thymopoietin, isoforms beta/gamma, TP beta/gamma, Thymopoietin-related peptide isoforms beta/gamma, TPRP isoforms beta/gamma, Thymopoietin, TP, Splenin, Thymopentin, TP5, TMPO, LAP2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.|
|Cellular Location||Nucleus inner membrane; Single-pass type II membrane protein. Note=Tightly associated with the nuclear lamina|
|Tissue Location||Expressed in many tissues. Most abundant in adult thymus and fetal liver|
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The protein encoded by this gene resides in the nucleusand may play a role in the assembly of the nuclear lamina, and thushelp maintain the structural organization of the nuclear envelope.It may function as a receptor for the attachment of lamin filamentsto the inner nuclear membrane. Mutations in this gene areassociated with dilated cardiomyopathy. Alternatively splicedtranscript variants encoding different isoforms have been noted forthis gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Craig, D.W., et al. Diabet. Med. 26(11):1090-1098(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Shaklai, S., et al. Eur. J. Cell Biol. 87(5):267-278(2008)
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