|Other Names||Mitochondrial tRNA-specific 2-thiouridylase 1, 281-, MTO2 homolog, TRMU, MTU1, TRMT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2- thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.|
|Tissue Location||Ubiquitous. Abundantly expressed in tissues with high metabolic rates including heart, liver, kidney, and brain.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the trmU family. It encodes amitochondria-specific tRNA-modifying enzyme that is required forthe 2-thio modification of 5-taurinomethyl-2-thiouridine tRNA-Lyson the wobble position of the anticodon.
Zeharia, A., et al. Am. J. Hum. Genet. 85(3):401-407(2009)Reiling, E., et al. Eur. J. Hum. Genet. 17(8):1056-1062(2009)de Moraes, V.C., et al. Biochem. Biophys. Res. Commun. 381(2):210-213(2009)Otaegui, D., et al. Audiol. Neurootol. 13(5):320-327(2008)Guan, M.X., et al. Am. J. Hum. Genet. 79(2):291-302(2006)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.