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TSEN2 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8NCE0
Clone Names 110901227
Peptide ID 110901227
Additional Information
Gene ID 80746
Other Names tRNA-splicing endonuclease subunit Sen2, tRNA-intron endonuclease Sen2, HsSen2, TSEN2, SEN2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TSEN2
Synonyms SEN2
Function Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre- mRNA 3'-end processing factors, establishing a link between pre- tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity.
Cellular Location Nucleus. Nucleus, nucleolus. Note=May be transiently localized in the nucleolus
Tissue Location Isoform 1 and isoform 2 are widely expressed at very low level.
Research Areas
Citations (0)

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This gene encodes one of the subunits of the tRNA splicingendonuclease. This endonuclease catalyzes the first step in RNAsplicing which is the removal of introns. Mutations in this genehave been associated with pontocerebellar hypoplasia type 2. Apseudogene has been identified on chromosome 4. Multiple transcriptvariants encoding different isoforms have been found for this gene.


Weitzer, S., et al. Nature 447(7141):222-226(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Ballif, B.A., et al. Mol. Cell Proteomics 3(11):1093-1101(2004)Paushkin, S.V., et al. Cell 117(3):311-321(2004)Nakayama, M., et al. Genome Res. 12(11):1773-1784(2002)

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$ 80.00
Cat# BP19095a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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