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UBAP2L Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q14157
Clone Names 110901235
Additional Information
Gene ID 9898
Other Names Ubiquitin-associated protein 2-like, Protein NICE-4, UBAP2L, KIAA0144, NICE4
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBAP2L (HGNC:29877)
Synonyms KIAA0144, NICE4
Function Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT- HSCs) (By similarity). Required for efficient formation of stress granules (PubMed:29395067).
Cellular Location Nucleus. Chromosome. Cytoplasm Cytoplasm, Stress granule Note=Associates with nuclear chromatin.
Tissue Location Ubiquitous..
Research Areas
Citations (0)
citation

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Background

UBAP2L contains 1 UBA domain and has 3 named isoforms. UBA domains are a commonly occurring sequence motif of approximately 45 amino acid residues that are found in diverse proteins involved in the ubiquitin/proteasome pathway, DNA excision-repair, and cell signalling via protein kinases. The function of this protein is not known.

References

Ichikawa, S., et al. J. Bone Miner. Res. 25(8):1821-1829(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Wang, Y.L., et al. J. Biol. Chem. 283(49):33808-33815(2008)Olsen, J.V., et al. Cell 127(3):635-648(2006)Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)

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$ 277.78
Cat# BP19097c
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