|Other Names||Replication factor C subunit 1, Activator 1 140 kDa subunit, A1 140 kDa subunit, Activator 1 large subunit, Activator 1 subunit 1, DNA-binding protein PO-GA, Replication factor C 140 kDa subunit, RF-C 140 kDa subunit, RFC140, Replication factor C large subunit, RFC1, RFC140|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA.|
|Tissue Location||Wide tissue distribution. Undetectable in placental tissue|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is the large subunit ofreplication factor C, which is a five subunit DNA polymeraseaccessory protein. Replication factor C is a DNA-dependent ATPasethat is required for eukaryotic DNA replication and repair. Theprotein acts as an activator of DNA polymerases, binds to the 3'end of primers, and promotes coordinated synthesis of both strands.It also may have a role in telomere stability. [provided byRefSeq].
Overmeer, R.M., et al. Mol. Cell. Biol. 30(20):4828-4839(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Arora, M., et al. Leukemia 24(8):1470-1475(2010)Galbiatti, A.L., et al. Mol. Biol. Rep. (2010) In press :Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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