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NCAPG Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9BPX3
Clone Names 100517167
Peptide ID 100517167
Additional Information
Gene ID 64151
Other Names Condensin complex subunit 3, Chromosome-associated protein G, Condensin subunit CAP-G, hCAP-G, Melanoma antigen NY-MEL-3, Non-SMC condensin I complex subunit G, XCAP-G homolog, NCAPG, CAPG, NYMEL3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NCAPG
Synonyms CAPG, NYMEL3
Function Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Cellular Location Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation Dissociation from chromosomes is observed in late telophase
Tissue Location Highly expressed in testis.
Research Areas
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Background

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

References

Okada, Y., et al. Hum. Mol. Genet. 19(11):2303-2312(2010)Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :Murphy, L.A., et al. Biochem. Biophys. Res. Commun. 377(3):1007-1011(2008)Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)

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$ 80.00
Cat# BP19113a
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