|Other Names||Synaptotagmin-1, Synaptotagmin I, SytI, p65, SYT1, SVP65, SYT|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Cytoplasm. Note=Synaptic vesicles and chromaffin granules|
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Provided below are standard protocols that you may find useful for product applications.
The synaptotagmins are integral membrane proteins ofsynaptic vesicles thought to serve as Ca(2+) sensors in the processof vesicular trafficking and exocytosis. Calcium binding tosynaptotagmin-1 participates in triggering neurotransmitter releaseat the synapse (Fernandez-Chacon et al., 2001 [PubMed11242035]).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Musch, M.W., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 298 (2), G203-G211 (2010) :Kathir, K.M., et al. Biochim. Biophys. Acta 1798(2):297-302(2010)Pattaro, C., et al. BMC Med. Genet. 11, 41 (2010) :Hamdan, F.F., et al. Ann. Neurol. 65(6):748-753(2009)
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