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SYT1 Antibody (Center K237) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P21579
Clone Names 111205012
Peptide ID 111205012
Additional Information
Gene ID 6857
Other Names Synaptotagmin-1, Synaptotagmin I, SytI, p65, SYT1, SVP65, SYT
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYT1
Synonyms SVP65, SYT
Function May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Cellular Location Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P21707}; Single- pass membrane protein {ECO:0000250|UniProtKB:P21707}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000250|UniProtKB:P21707}. Cytoplasm {ECO:0000250|UniProtKB:P21707}. Note=Synaptic vesicles and chromaffin granules. {ECO:0000250|UniProtKB:P21707}
Tissue Location Expressed in melanocytes (PubMed:23999003).
Research Areas
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Background

The synaptotagmins are integral membrane proteins ofsynaptic vesicles thought to serve as Ca(2+) sensors in the processof vesicular trafficking and exocytosis. Calcium binding tosynaptotagmin-1 participates in triggering neurotransmitter releaseat the synapse (Fernandez-Chacon et al., 2001 [PubMed11242035]).

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Musch, M.W., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 298 (2), G203-G211 (2010) :Kathir, K.M., et al. Biochim. Biophys. Acta 1798(2):297-302(2010)Pattaro, C., et al. BMC Med. Genet. 11, 41 (2010) :Hamdan, F.F., et al. Ann. Neurol. 65(6):748-753(2009)

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$ 80.00
Cat# BP19117c
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