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PES1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O00541 |
|---|---|
| Clone Names | 100517064 |
| Gene ID | 23481 |
|---|---|
| Other Names | Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028}, PES1 {ECO:0000255|HAMAP-Rule:MF_03028} |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PES1 {ECO:0000255|HAMAP-Rule:MF_03028} |
|---|---|
| Function | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. |
| Cellular Location | Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli. {ECO:0000255|HAMAP- Rule:MF_03028} |
| Tissue Location | Significant levels are detected in a variety of cancer cell lines, including glioblastoma, breast carcinoma, colon carcinoma and cervical carcinoma cells. Levels are abnormally elevated in malignant tumors of astrocytic origin |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein that is abnormally elevated inmalignant tumors of astrocytic origin. It is a strongly conservedgene containing a BRCT domain that is essential for the activity ofthis gene product. The gene plays a crucial role in cellproliferation and may be necessary for oncogenic transformation andtumor progression.
References
Zhang, J., et al. Acta Biochim. Biophys. Sin. (Shanghai) 41(12):991-997(2009)Li, J., et al. Cancer Sci. 100(12):2255-2260(2009)Rikova, K., et al. Cell 131(6):1190-1203(2007)Rohrmoser, M., et al. Mol. Cell. Biol. 27(10):3682-3694(2007)Grimm, T., et al. Nucleic Acids Res. 34(10):3030-3043(2006)
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