|Other Names||Acid-sensing ion channel 3, ASIC3, hASIC3, Amiloride-sensitive cation channel 3, Neuronal amiloride-sensitive cation channel 3, Testis sodium channel 1, hTNaC1, ASIC3, ACCN3, SLNAC1, TNAC1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ACCN3, SLNAC1, TNAC1|
|Function||Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells (By similarity).|
|Tissue Location||Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis.|
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This gene encodes a member of the degenerin/epithelialsodium channel (DEG/ENaC) superfamily. The members of this familyare amiloride-sensitive sodium channels that contain intracellularN and C termini, two hydrophobic transmembrane regions, and a largeextracellular loop, which has many cysteine residues with conservedspacing. The member encoded by this gene is an acid sensor and mayplay an important role in the detection of lasting pH changes. Inaddition, a heteromeric association between this member and ACCN1has been observed as proton-gated channels sensitive to gadolinium.Alternative splicing of this gene generates three transcriptvariants encoding distinct isoforms.
Borzan, J., et al. Anesthesiology 113(3):647-654(2010)Wu, S., et al. Clin. Chim. Acta 411 (15-16), 1132-1136 (2010) :Ko, Y.L., et al. J. Hypertens. 26(11):2154-2160(2008)Su, X., et al. J. Biol. Chem. 281(48):36960-36968(2006)Jones, N.G., et al. J. Neurosci. 24(48):10974-10979(2004)
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