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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   KDELR1 Antibody (C-term) Blocking Peptide   

KDELR1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P24390
Clone Names 110826222
Peptide ID 110826222
Additional Information
Gene ID 10945
Other Names ER lumen protein-retaining receptor 1, KDEL endoplasmic reticulum protein retention receptor 1, KDEL receptor 1, Putative MAPK-activating protein PM23, KDELR1, ERD21
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ERD2.1
Function Required for the retention of luminal endoplasmic reticulum resident proteins via vesicular recycling. This receptor recognizes the C-terminal K-D-E-L motif. COPI-coated transport intermediates, either in the form of round vesicles or as tubular processes, mediate retrograde traffic of the KDEL receptor-ligand complexes. Also required for normal vesicular traffic through the Golgi.
Cellular Location Cytoplasmic vesicle, COPI-coated vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane
Research Areas
Citations (0)

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Retention of resident soluble proteins in the lumen of theendoplasmic reticulum (ER) is achieved in both yeast and animalcells by their continual retrieval from the cis-Golgi, or apre-Golgi compartment. Sorting of these proteins is dependent on aC-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) inanimal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. Thisprocess is mediated by a receptor that recognizes, and binds thetetrapeptide-containing protein, and returns it to the ER. Inyeast, the sorting receptor encoded by a single gene, ERD2, whichis a seven-transmembrane protein. Unlike yeast, several humanhomologs of the ERD2 gene, constituting the KDEL receptor genefamily, have been described. The protein encoded by this gene wasthe first member of the family to be identified, and it encodes aprotein structurally and functionally similar to the yeast ERD2gene product.


Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Breuza, L., et al. J. Biol. Chem. 279(45):47242-47253(2004)Bard, F., et al. J. Biol. Chem. 278(47):46601-46606(2003)Yamamoto, K., et al. J. Biol. Chem. 278(36):34525-34532(2003)Matsuda, A., et al. Oncogene 22(21):3307-3318(2003)

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$ 80.00
Cat# BP19130b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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