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DMRT1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y5R6 |
|---|---|
| Clone Names | 110826102 |
| Gene ID | 1761 |
|---|---|
| Other Names | Doublesex- and mab-3-related transcription factor 1, DM domain expressed in testis protein 1, DMRT1, DMT1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DMRT1 |
|---|---|
| Synonyms | DMT1 |
| Function | Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}. |
| Tissue Location | Testis-specific. Expressed in prostate cancer (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is found in a cluster with two other members ofthe gene family, having in common a zinc finger-like DNA-bindingmotif (DM domain). The DM domain is an ancient, conserved componentof the vertebrate sex-determining pathway that is also a keyregulator of male development in flies and nematodes. This geneexhibits a gonad-specific and sexually dimorphic expressionpattern. Defective testicular development and XY feminization occurwhen this gene is hemizygous.
References
Kang, J.U., et al. Int. J. Oncol. 37(2):327-335(2010)Turnbull, C., et al. Nat. Genet. 42(7):604-607(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Krentz, A.D., et al. Proc. Natl. Acad. Sci. U.S.A. 106(52):22323-22328(2009)Cheng, H.H., et al. Cell Res. 16(4):389-393(2006)
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